What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?

نویسندگان

  • J-P Pelletier
  • C Cooper
  • C Peterfy
  • J-Y Reginster
  • M-L Brandi
  • O Bruyère
  • R Chapurlat
  • F Cicuttini
  • P G Conaghan
  • M Doherty
  • H Genant
  • G Giacovelli
  • M C Hochberg
  • D J Hunter
  • J A Kanis
  • M Kloppenburg
  • J-D Laredo
  • T McAlindon
  • M Nevitt
  • J-P Raynauld
  • R Rizzoli
  • C Zilkens
  • F W Roemer
  • J Martel-Pelletier
  • A Guermazi
چکیده

Knee osteoarthritis is associated with structural changes in the joint. Despite its many drawbacks, radiography is the current standard for evaluating joint structure in trials of potential disease-modifying osteoarthritis drugs. MRI is a non-invasive alternative that provides comprehensive imaging of the whole joint. Frequently used MRI measurements in knee osteoarthritis are cartilage volume and thickness; others include synovitis, synovial fluid effusions, bone marrow lesions (BML) and meniscal damage. Joint replacement is considered a clinically relevant outcome in knee osteoarthritis; however, its utility in clinical trials is limited. An alternative is virtual knee replacement on the basis of symptoms and structural damage. MRI may prove to be a good alternative to radiography in definitions of knee replacement. One of the MRI parameters that predicts knee replacement is medial compartment cartilage volume/thickness, which correlates with radiographic joint space width, is sensitive to change, and predicts outcomes in a continuous manner. Other MRI parameters include BML and meniscal lesions. MRI appears to be a viable alternative to radiography for the evaluation of structural changes in knee osteoarthritis and prediction of joint replacement.

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عنوان ژورنال:
  • Annals of the rheumatic diseases

دوره 72 10  شماره 

صفحات  -

تاریخ انتشار 2013